منابع مشابه
Effect of ACE inhibition on glomerular permselectivity and tubular albumin concentration in the renal ablation model.
Despite the central role of tubular plasma proteins that characterize progressive kidney diseases, protein concentrations along the nephron in pathological conditions have not been quantified so far. We combined experimental techniques and theoretical analysis to estimate glomerular and tubular levels of albumin in the experimental model of 5/6 nephrectomy (Nx) in the rat, with or without angio...
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Rat kidney endothelial cell morphology was examined after introducing iron colloid particles of positive or negative charge to investigate the relationship between the electric charge and permeation through the glomerular capillary. The kidneys were first perfused with Hanks’ solution through the renal arteries and then with iron colloid particles of positive or negative charge. The iron colloi...
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Changes in glomerular permselectivity are the physiological basis for proteinuria, which typically accompanies chronic kidney disease. Traditionally changes in the sizerestrictive properties of the glomerular barrier have been quantified by measuring the fractional clearance ( ) of exogenous infused dextrans and interpreting the results using the hindered transport theory for uncharged, solid s...
متن کاملDirect antiGBM antibody induced alterations in glomerular permselectivity.
The glomerular fixation of anti-glomerular-basement-membrane (antiGBM) antibody is associated with complement activation, neutrophil accumulation, and renal injury. This injury manifests both as an increase in the rate of urinary protein excretion and altered renal hemodynamic characteristics. We have utilized an isolated perfused kidney system (IPK) to assess the capacity of antiGBM antibody t...
متن کاملCirculating Glycated Albumin and Glomerular Anionic Charges
Aiming to discern the mechanisms by which circulating glycated albumin alters the glomerular filtration properties that lead to glomerular dysfunction in diabetes, the authors studied the distribution and densities of anionic charges through the rat glomerular wall upon intravascular infusion of Amadori products, as well as in various conditions of increased glomerular permselectivity. Polylysi...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2004
ISSN: 1460-2385
DOI: 10.1093/ndt/gfg607